A specific microRNA profile as predictive biomarker for systemic treatment in patients with metastatic colorectal cancer.
Dennis PoelElske C GootjesLotte BakkerusWim TrypsteenHenk DekkerHans J van der VlietNicole C T van GriekenCornelis VerhoefTineke E BuffartHenk M W VerheulPublished in: Cancer medicine (2020)
The additive predictive value to clinical parameters of the tissue-derived six miRNA profile for clinical benefit could not be validated in patients with mCRC treated with first-line systemic therapy. Although miR-92a-3p and miR-98-5p serum levels improved the predictive value of clinical parameters, it remained insufficient for clinical decision-making.
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