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Remodelling of cAMP dynamics within the SERCA2a microdomain in heart failure with preserved ejection fraction caused by obesity and type 2 diabetes.

Ping LaiSusanne S HilleHariharan SubramanianRobert WeigmanPia RoserOliver J MüllerViacheslav O NikolaevKirstie A De Jong
Published in: Cardiovascular research (2023)
These newly identified alterations of cAMP dynamics at the subcellular level in HFpEF should provide mechanistic understanding of microdomain remodelling and pave the way towards new therapies.
Keyphrases
  • type diabetes
  • insulin resistance
  • binding protein
  • metabolic syndrome
  • weight loss
  • glycemic control
  • cardiovascular disease
  • protein kinase
  • adipose tissue
  • skeletal muscle
  • physical activity