Remodelling of cAMP dynamics within the SERCA2a microdomain in heart failure with preserved ejection fraction caused by obesity and type 2 diabetes.

Ping LaiSusanne S HilleHariharan SubramanianRobert WeigmanPia RoserOliver J Müller Viacheslav O Nikolaev Kirstie A De Jong

Published in: Cardiovascular research (2023)

These newly identified alterations of cAMP dynamics at the subcellular level in HFpEF should provide mechanistic understanding of microdomain remodelling and pave the way towards new therapies.

Keyphrases

type diabetes
insulin resistance
binding protein
metabolic syndrome
weight loss
glycemic control
cardiovascular disease
protein kinase
adipose tissue
skeletal muscle
physical activity