Rare-earth orthovanadate nanoparticles trigger Ca2+-dependent eryptosis.

Svetlana L YefimovaAnatolii OnishchenkoVladimir KlochkovValeriy MyasoedovYurii KotLiliya TryfonyukOleksandr KnigavkoPavel MaksimchukUmut KökbaşYuliia Kalashnyk-VakulenkoAndrii ArkatovVladyslav KhanzhynVolodymyr ProkopyukIryna VyshnytskaAnton S Tkachenko

Published in: Nanotechnology (2023)

Both internalized GdVO4:Eu3+ and non-internalized LaVO4:Eu3+ nanoparticles (80 mg / L) promote eryptosis of erythrocytes after a 24 h exposure in vitro via Ca2+ signaling without involvement of oxidative stress. Eryptosis is a promising model for assessing nanotoxicity.

Keyphrases

oxidative stress
protein kinase
dna damage
ischemia reperfusion injury
walled carbon nanotubes
induced apoptosis
signaling pathway
heat shock