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Serum of myeloproliferative neoplasms stimulates hematopoietic stem and progenitor cells.

Richard K LubberichThomas WalendaTamme W GoeckeKlaus StrathmannSusanne IsfortTim H BrümmendorfSteffen KoschmiederWolfgang Wagner
Published in: PloS one (2018)
Our results indicate that serum derived from patients with MPN comprises activating feedback signals that stimulate the HPCs-and this stimulatory signal may result in a viscous circle that further accelerates development of the disease.
Keyphrases
  • signaling pathway