Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease.

Parker C WilsonAmit VermaYasuhiro YoshimuraYoshiharu MutoHaikuo LiNicole P MalvinEryn E DixonBenjamin D Humphreys

Published in: Genome biology (2024)

We hypothesize that LOY is an indicator of increased DNA damage and potential marker of cellular senescence that can be applied to single-cell datasets in other tissues.

Keyphrases

dna damage
single cell
rna seq
dna repair
oxidative stress
gene expression
high throughput
copy number
human health
endothelial cells
risk assessment
stress induced
genome wide
climate change