Increased Abundances of CD16 + Non-Classical Monocytes Accompany with Elevated Monocytic PD-L1 and CD4 + T Cell Disturbances in Oropharyngeal Cancer.

We conclude that oropharyngeal cancer, as a malignancy from a lymphoid-tissue-rich anatomical region, has a strong systemic impact on the differentiation and regulation of circulating innate and adaptive immune cells. Further comprehensive investigations are required for the possible future usability of the described immunological alterations as bioliquid parameters for prognosis or therapy response prediction.