Placental Methylglyoxal in Preeclampsia: Vascular and Biomarker Implications.
Philippe VangriekenSalwan Al-NasiryAlex H V RemelsPaul M H SchiffersEmma B N J JanssenStefanie NassJean L J M ScheijenMarc E A SpaandermanMiranda T SchramPublished in: Hypertension (Dallas, Tex. : 1979) (2024)
This study reveals the accumulation of placental MGO in preeclampsia and upon exposure to hypoxia, demonstrates how MGO can contribute to vascular impairment, and highlights plasma CML and MG-H1 levels as promising early biomarkers for preeclampsia.