Exploring the Therapeutic Mechanism of Tingli Dazao Xiefei Decoction on Heart Failure Based on Network Pharmacology and Experimental Study.

Dan-Dan ZhaoXiao-Qing ZhangTao YangQian LiuZhen-Zhen LanXiao-Li YangHui-Yan Qu Hua Zhou

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

Combining network pharmacological analysis and experimental validation, this study verified that TDXD could improve cardiac function and protect against cardiac injury by inhibiting the activation of PI3K/Akt and MAPK signaling pathways.

Keyphrases

pi k akt
signaling pathway
heart failure
cell cycle arrest
cell proliferation
induced apoptosis
epithelial mesenchymal transition
left ventricular
atrial fibrillation
cell death
oxidative stress
data analysis
network analysis
acute heart failure