Evaluation of KRAS, NRAS and BRAF mutational status and microsatellite instability in early colorectal carcinomas invading the submucosa (pT1): towards an in-house molecular prognostication for pathologists?

Amélie BourhisCaterina De LucaMélanie CariouElena VigliarFanny BarelFloriana ConticelliPascale MarcorellesJean-Baptiste NousbaumMichel RobaszkiewiczLaura SamaisonBogdan BadicLaurent DoucetGiancarlo Troncone Arnaud Uguen

Published in: Journal of clinical pathology (2020)

Although being feasible using the fully automated Idylla method as well as NGS, the molecular testing of KRAS, NRAS, BRAF and MSS/MSI status does not seem useful for prognostic purpose in the field of pT1 CRC.

Keyphrases

wild type
machine learning
single molecule
deep learning
high throughput
high grade