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Identification and Validation of T-Cell Exhaustion Signature for Predicting Prognosis and Immune Response in Pancreatic Cancer by Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data.

Yaowu ZhuLi TanDanju LuoXiong Wang
Published in: Diagnostics (Basel, Switzerland) (2024)
We established and validated a T-cell exhaustion-related prognostic signature for patients with PACA. Moreover, our study suggests that SPOCK2 is a novel marker of exhausted CD8+ T cells.
Keyphrases
  • single cell
  • immune response
  • rna seq
  • electronic health record
  • big data
  • dendritic cells
  • machine learning
  • deep learning