Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity.

Guiomar Pérez-MorenoPaula Sánchez-CarrascoLuis Miguel Ruiz-PérezNils Gunnar JohanssonSylke MüllerBeatriz BaragañaShahienaz Emma HamptonIan Hugh GilbertMarcel KaiserSandipan SarkarThiyagamurthy PanduranganVijeesh KumarDolores Gonzalez Pacanowska

Published in: Malaria journal (2019)

These results strongly confirm the pivotal and essential role of dUTPase in pyrimidine biosynthesis of P. falciparum intraerythrocytic stages.

Keyphrases

plasmodium falciparum
molecular docking
cell wall
structure activity relationship
molecular dynamics simulations