Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort.
Rosalieke E WiegelMaud J H KarstenIgna F ReijndersLenie van RossemSten P WillemsenAnnemarie G M G J MuldersAnton H J KoningEric A P SteegersA H Jan DanserRégine Patricia Maria Steegers-TheunissenPublished in: Reproductive biology and endocrinology : RB&E (2021)
The absence of a CL, resulting in low prorenin concentrations, associates with low uterine artery pulsatility and resistance, while high prorenin concentrations associate with a low utero-placental vascular volume and weight. These data support a scenario in which excess prorenin, by upregulating angiotensin II, increases uterine resistance, thereby preventing normal placental (vascular) development, and increasing the risk of small-for-gestational age deliveries. Simultaneously, high aldosterone concentrations, by ensuring volume expansion, exert the opposite.