Investigation of cell death mechanism and activity of esculetin-loaded PLGA nanoparticles on insulinoma cells in vitro.

Ayse Karatug-Kacar Fatemeh Bahadori Serife Evrim Kepekci Tekkeli Gulacti Topcu Sehnaz Bolkent

Published in: The Journal of pharmacy and pharmacology (2020)

The results revealed that esculetin is able to show its anti-tumor afficacy after loading to PLGA nano-micelles and nano-encapsulation intensifies its cytotoxic activity in vitro. Current study shows that esculetin and its nano formulations are promising agents in treatment of insulinoma.

Keyphrases

drug delivery
cell death
cell cycle arrest
drug release
cancer therapy
induced apoptosis
single cell
oxidative stress
bone regeneration
cell proliferation
anti inflammatory