Neutralization and receptor use of infectious culture-derived rat hepacivirus as a model for HCV.

Raphael WolfisbergCaroline E ThorseliusEduardo SalinasElizabeth ElrodSheetal TrivediLouise NielsenUlrik FahnøeAmit KapoorArash GrakouiCharles M RiceJens BukhKenn HolmbeckTroels Kasper Høyer Scheel

Published in: Hepatology (Baltimore, Md.) (2022)

The RHV-rn1 infectious cell culture system enables studies of humoral immune responses against hepacivirus infection. Moreover, recapitulation of the entire RHV-rn1 infectious cycle in cell culture will facilitate reverse genetic studies and the exploration of tropism and virus-host interactions.

Keyphrases

immune response
case control
hepatitis c virus
oxidative stress
toll like receptor
dendritic cells
human immunodeficiency virus
gene expression
inflammatory response
copy number