Profiling the peripheral immune response to ex vivo TNF stimulation in untreated juvenile idiopathic arthritis using single cell RNA sequencing.

Kathleen J ImbachNicole J TreadwayVaishali PrahaladAstrid KostersDalia ArafatMeixue DuanTalia GergelyLori A PonderShanmuganathan ChandrakasanEliver E B GhosnSampath PrahaladGreg Gibson

Published in: Pediatric rheumatology online journal (2023)

These results support the development of personalized immune-profiling combined with ex-vivo immune stimulation for evaluation of patient-specific modes of immune cell activity in autoimmune rheumatic disease.

Keyphrases

single cell
juvenile idiopathic arthritis
rna seq
immune response
rheumatoid arthritis
high throughput
disease activity
multiple sclerosis
dendritic cells
toll like receptor
systemic lupus erythematosus