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Gata3 hypermethylation and Foxp3 hypomethylation are associated with sustained protection and bystander effect following epicutaneous immunotherapy in peanut-sensitized mice.

Lucie MondouletV DioszeghyF BusatoC PlaquetV DhelftK BethuneL LeclereC DaviaudM LigouisH SampsonC DupontJorg Tost
Published in: Allergy (2018)
Our study demonstrates that EPIT leads to a unique and stable epigenetic signature in specific T-cell compartments with downregulation of Th2 key regulators and upregulation of Treg transcription factors, likely explaining the sustainability of protection and the observed bystander effect.
Keyphrases
  • transcription factor
  • cell proliferation
  • gene expression
  • signaling pathway
  • regulatory t cells
  • type diabetes
  • skeletal muscle
  • high fat diet induced
  • long non coding rna
  • dendritic cells