Selective oxidation of alcohol- d 1 to aldehyde- d 1 using MnO 2 .
Hironori OkamuraYoko YasunoAtsushi NakayamaKatsushi KumadakiKohei KitsuwaKeita OzawaYusaku TamuraYuki YamamotoTetsuro ShinadaPublished in: RSC advances (2021)
The selective oxidation of alcohol- d 1 to prepare aldehyde- d 1 was newly developed by means of NaBD 4 reduction/activated MnO 2 oxidation. Various aldehyde- d 1 derivatives including aromatic and unsaturated aldehyde- d 1 can be prepared with a high deuterium incorporation ratio (up to 98% D). Halogens (chloride, bromide, and iodide), alkene, alkyne, ester, nitro, and cyano groups in the substrates are tolerated under the mild conditions.