FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients.
Valentina V MiroshnikovaEkaterina A PolyakovaIrina A PobozhevaAleksandra A PanteleevaNatalia D RazgildinaDiana A KolodinaOlga D BelyaevaOlga A BerkovichSofya N PchelinaElena I BaranovaPublished in: Genetics and molecular biology (2021)
Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coronary artery disease (CAD). Omentin-1 and FABP4 mRNA levels in EAT and paired subcutaneous adipose tissue (SAT) as well as adipokine serum concentrations were assessed in 77 individuals (61 with CAD; 16 without CAD (NCAD)). EAT FABP4 mRNA level was decreased in obese CAD patients when compared to obese NCAD individuals (p=0.001). SAT FABP4 mRNA level was decreased in CAD patients compared to NCAD individuals without respect to their obesity status (p=0.001). Omentin-1 mRNA level in EAT and SAT did not differ between the CAD and NCAD groups. These findings suggest that omentin-1 gene expression in adipose tissue is not changed during CAD; downregulated FABP4 gene expression in SAT is associated with CAD while EAT FABP4 gene expression is decreased only in obesity-related CAD.
Keyphrases
- adipose tissue
- binding protein
- coronary artery disease
- gene expression
- insulin resistance
- metabolic syndrome
- end stage renal disease
- weight loss
- dna methylation
- type diabetes
- high fat diet
- chronic kidney disease
- ejection fraction
- peritoneal dialysis
- percutaneous coronary intervention
- heart failure
- prognostic factors
- physical activity
- coronary artery bypass grafting
- weight gain
- high fat diet induced
- cardiovascular disease
- acute coronary syndrome
- patient reported outcomes
- risk factors
- skeletal muscle