Whole tumor kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flow.

Daniel R McGowanMichael SkwarskiBartlomiej W PapiezRuth E MacphersonFergus V GleesonJulia A SchnabelGeoff S HigginsJohn D Fenwick

Published in: EJNMMI research (2018)

Time-courses of whole tumor FMISO uptake by advanced stage NSCLC are described best by an irreversible three-tissue compartment model. The K1 values obtained from fits of the irreversible three-tissue model correlated strongly with independent blood flow measurements obtained from perfusion CT (r = 0.81).

Keyphrases

blood flow
contrast enhanced
computed tomography
dual energy
magnetic resonance imaging
positron emission tomography
image quality
small cell lung cancer
magnetic resonance
single cell
pet ct
advanced non small cell lung cancer
mesenchymal stem cells
bone marrow
tyrosine kinase