Impaired antibacterial immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
Alexandra TsitsiklisBeth Shoshana ZhaAshley ByrneCatherine DevoeSophia LevanElze RackaityteSara SunshineEran MickRajani GhaleAlejandra JaureguiAartik SarmaNorma NeffPaula Hayakawa SerpaThomas J DeissAmy KistlerSidney A CarrilloKarl Mark AnselAleksandra LeligdowiczStephanie A ChristensonNorman JonesBing WuSpyros DarmanisMichael A MatthaySusan V LynchJoseph L DeRisinull nullCarolyn M HendricksonKirsten N KangelarisMatthew F KrummelPrescott G WoodruffDavid J ErleOren RosenbergCarolyn S CalfeeCharles R LangelierPublished in: medRxiv : the preprint server for health sciences (2021)
COVID-19 patients with secondary bacterial pneumonia have impaired immune signaling and lung microbiome changes weeks before onset.