Impact of apoptotic circulating tumor cells (aCTC) in metastatic breast cancer.

Thomas M DeutschSabine RiethdorfJuliane NeesAndreas D HartkopfBirgitt SchönfischChristoph DomschkeMartin R SprickFlorian SchützSara Y BruckerStefan StefanovicChristof SohnKlaus PantelAndreas TrumppAndreas SchneeweissMarkus Wallwiener

Published in: Breast cancer research and treatment (2016)

Intact and aCTC are predictive of outcome in MBC. Apoptotic CTC counts ≥ 5/7.5 ml in conjunction with iCTC at baseline have an independent unfavorable prognostic impact on OS. Decreasing aCTCKIN at ≥ 5/7.5 ml in serial enumeration is associated with favorable outcome. Therefore, separate enumeration of iCTC and aCTC is useful in tailoring systemic treatment.

Keyphrases

circulating tumor cells
metastatic breast cancer
cell death
circulating tumor
anti inflammatory
drug induced