Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension.

Anna DikalovaDaniel J FehrenbachVladimir MayorovAlexander PanovMingfang AoLouise LantierVenkataraman AmarnathMarcos G LopezFrederic T BillingsMichael N Sack Sergey I Dikalov

Published in: Circulation research (2024)

These data support the pathogenic role of CypD acetylation in endothelial dysfunction and hypertension. We suggest that targeting cytotoxic mitochondrial isolevuglandins and GCN5L1 reduces CypD acetylation, which may be beneficial in cardiovascular disease.

Keyphrases

blood pressure
cardiovascular disease
oxidative stress
histone deacetylase
big data
machine learning
metabolic syndrome
artificial intelligence