C-reactive protein impairs immune response of CD8 + T cells via FcγRIIb-p38MAPK-ROS axis in multiple myeloma.

Jinxing JiangZiyi PengJunying WangMengping ChenYike WanHonghui HuangZhiqiang LiuJingya WangJian Hou

Published in: Journal for immunotherapy of cancer (2023)

T cells via FcγRIIb-p38MAPK-ROS signaling pathway. The study casted new insights into the role of CRP in anti-myeloma immunity, providing implications for future immunotherapy in MM.

Keyphrases

multiple myeloma
immune response
signaling pathway
cell death
dna damage
reactive oxygen species
pi k akt
current status
dendritic cells
toll like receptor
cell proliferation
induced apoptosis
oxidative stress
inflammatory response