Host methylation predicts SARS-CoV-2 infection and clinical outcome.
Iain R KonigsbergBret BarnesMonica CampbellElizabeth DavidsonYingfei ZhenOlivia PallisardMeher Preethi BoorgulaCorey CoxDebmalya NandySouvik SealKristy CrooksEvan SticcaGenelle F HarrisonAndrew HopkinsonAlexis VestCosby G ArnoldMichael G KahnDavid P KaoBrett R PetersonStephen J WicksDebashis GhoshSteve HorvathWanding ZhouRasika A MathiasPaul J NormanRishi PorechaIvana V YangChristopher R GignouxAndrew A MonteAlem TayeKathleen C BarnesPublished in: Communications medicine (2021)
In summary, the strong COVID-19-specific epigenetic signature in peripheral blood driven by key immune-related pathways related to infection status, disease severity, and clinical deterioration provides insights useful for diagnosis and prognosis of patients with viral infections.