Azoxymethane-induced carcinogenesis-like model of mouse intestine and mouse embryonic stem cell-derived intestinal organoids.

Hatice Burcu ŞişliSelinay Şenkal TurhanEzgi Bulut OkumuşÖzüm Begüm BökeÖzüm ErdoğmuşBerke KülEngin SümerAyşegül DoĞan

Published in: Molecular biology reports (2024)

We successfully developed simple carcinogenesis-like models using mESC-based and Lgr5 + stem cell-based intestinal organoids. Intestinal organoid based carcinogenesi models might be used for personalized cancer therapy in the future.

Keyphrases

stem cells
cancer therapy
high glucose
oxidative stress
drug induced
bone marrow