Bispecific immune cell engager enhances the anticancer activity of CD16+ NK cells and macrophages in vitro, and eliminates cancer metastasis in NK humanized NOG mice.

Shahryar Khoshtinat NikkhoiGe YangHajar OwjiMayara Grizotte-LakeRick I CohenLazaro Gil GonzalezMohammad MassumiArash Hatefi

Published in: Journal for immunotherapy of cancer (2024)

Collectively, our in vivo findings underscore BiKE:E5C1's potential as an immune cell engager capable of activating immune cells for cancer cell elimination, thereby expanding the arsenal of available BiKEs for cancer immunotherapy.

Keyphrases

nk cells
papillary thyroid
signaling pathway
squamous cell
high fat diet induced
childhood cancer
metabolic syndrome
young adults
adipose tissue
insulin resistance