Mast cells and sphingosine-1-phosphate underlie prelesional remodeling in a mouse model of eczema.
P A WedmanA AladhamiA P ChumanevichJ W FuselerCarole A OskeritzianPublished in: Allergy (2017)
We describe MC and S1P as novel pathogenic effectors that initiate remodeling in AD prior to any skin lesions and reveal the significance of LPS in OVA used in most studies, thus mimicking natural antigen (Ag) exposure.