Anti-Inflammatory Effects of Glucagon-Like Peptide-1 Receptor Agonists via the Neuroimmune Axis.
Susanna FangChi Kin WongPublished in: DNA and cell biology (2024)
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have shown efficacy in the treatment of metabolic disease-related complications, partially attributable to their anti-inflammatory properties. However, the specific cell types and pathways involved in these effects were not fully understood. A recent study by Wong et al. demonstrated the importance of the brain GLP-1R in mediating the anti-inflammatory effects of GLP-1RAs in Toll-like receptor and sepsis-mediated inflammation. In this discussion, we review the existing literature on the action of GLP-1RAs in inflammation and explore the implications of these recent findings.
Keyphrases
- toll like receptor
- anti inflammatory
- wild type
- oxidative stress
- nuclear factor
- inflammatory response
- systematic review
- immune response
- intensive care unit
- acute kidney injury
- single cell
- cell therapy
- white matter
- stem cells
- risk factors
- brain injury
- multiple sclerosis
- combination therapy
- drug induced
- subarachnoid hemorrhage