Acryl-3,5-bis(2,4-difluorobenzylidene)-4-piperidone targeting cellular JUN proto-oncogene, AP-1 transcription factor subunit inhibits head and neck squamous cell carcinoma progression.
Levi ArnoldJuan Pineda GomezMichael BarryMarrion YapLaura JacksonThuc LyDavid StandingSubhash B PadhyeBernhard BiersackShrikant AnantSufi Mary ThomasPublished in: Exploration of targeted anti-tumor therapy (2023)
A-DiFiD targets c-Jun, a clinical HNSCC driver, with potent anti-tumor effects.