The combination of PD-1 blockade with interferon-α has a synergistic effect on hepatocellular carcinoma.
Ying ZhuMo ChenDa XuTian-En LiZe ZhangJian-Hua LiXiang-Yu WangXin YangLu LuHu-Liang JiaQiong-Zhu DongLun-Xiu QinPublished in: Cellular & molecular immunology (2022)
These results indicate that in addition to initiating the antitumor immune response itself, Peg-IFNα can also generate a microenvironment favoring PD-1 blockade. Thus, the combination of Peg-IFNα and PD-1 blockade can be a promising strategy for HCC.