Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation.

Shen-Zhao LuYong-Shun GuoPei-Zhou LiangShu-Zhen ZhangShu YinYan-Qing YinXiao-Min WangFei DingXiao-Song GuJia-Wei Zhou

Published in: Translational neurodegeneration (2019)

This study reveals a novel function for CRYAB as a natural inhibitor of astrocytic autophagy and shows that knockdown of CYRAB may provide a therapeutic target against proteinopathies such as synucleinopathies.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress