Molecular profiling and analysis of genetic aberrations aimed at identifying potential therapeutic targets in fibrolamellar carcinoma of the liver.

Imane El DikaAnita S BowmanMichael F BergerMarinela CapanuJoanne F ChouRyma BenayedAhmet ZehirJinru ShiaEileen M O'ReillyDavid S KlimstraDavid B SolitGhassan K Abou-Alfa

Published in: Cancer (2020)

The DNAJB1-PRKACA fusion transcript is nonspecific and nonsensitive to FLC. Its potential therapeutic value currently is under evaluation. Opportunities currently are under development for therapy that may be driven or related to the DNAJB1-PRKACA fusion transcript or any therapeutic target identified from next-generation sequencing in patients with FLC.

Keyphrases

copy number
rna seq
single cell
genome wide
stem cells
single molecule
human health
gene expression