Vanillic Acid Ameliorates Demyelination in a Cuprizone-Induced Multiple Sclerosis Rat Model: Possible Underlying Mechanisms.

Sally M SafwatMahmoud El TohamyMoutasem Salih AboonqAmaal AlrehailiAhmad A Assinnari Abdulrahman S BahashwanAhmed A ElGendyAbdelaziz M Hussein

Published in: Brain sciences (2023)

The current study demonstrated a neuroprotective effect for VA against the Cup-induced demyelinating rat model. This effect might be precipitated by the inhibition of inflammation, oxidative stress, and apoptosis.

Keyphrases

oxidative stress
diabetic rats
multiple sclerosis
high glucose
dna damage
ischemia reperfusion injury
induced apoptosis
drug induced
endoplasmic reticulum stress
cell death
endothelial cells
mouse model
white matter
brain injury
signaling pathway
blood brain barrier
cerebral ischemia
subarachnoid hemorrhage