Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size.
Rebecca FaresjöGillian BonviciniXiaotian T FangXimena AguilarDag SehlinStina SyvanenPublished in: Fluids and barriers of the CNS (2021)
A smaller size and lower TfR1 avidity are likely important for fast parenchymal delivery, while elimination of brain-associated bispecific antibodies may not be dependent on these characteristics.