Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion.

Íngrid Martí-PàmiesRobrecht ThoonenMichael P MorleyLauren GravesJesus Tamez Alex CaplanKendra McDaidVincent Yao Allyson G Hindle Robert E GersztenLaurie A FarrellLi LiYu-Hua TsengGerson Profeta de SouzaEmmanuel S BuysDonald B Bloch Marielle Scherrer-Crosbie

Published in: Circulation research (2023)

The results of this study suggest a cardioprotective role of BAT and BMP3b, a protein secreted by BAT, in a model of I/R injury. Interventions increasing BMP3b levels or targeting Smad 1/5 may represent novel therapeutic approaches to decrease myocardial damage in I/R injury.

Keyphrases

mesenchymal stem cells
adipose tissue
left ventricular
bone regeneration
oxidative stress
physical activity
metabolic syndrome
bone marrow
drug delivery