Dual-Functional Implants with Antibacterial and Osteointegration-Promoting Performances.
Yujie SunYu-Qing ZhaoQiang ZengYu-Wei WuYang HuShun DuanZhihui TangFu-Jian XuPublished in: ACS applied materials & interfaces (2019)
Multifunctional antibacterial materials have great significance for treating biomedical device-associated infections (BAIs). In the present work, a facile and rational strategy was developed to produce dual-functional implants with antibacterial and osteointegration-promoting properties for the treatment of BAI. A titanium implant, as a representative demo of implants, was first functionalized with ethanediamine-functionalized poly(glycidyl methacrylate) (PGED) brushes. Then, low-molecular-weight quaternized polyethyleneimine (QPEI, a cationic antibacterial agent) and alendronate (ALN, a clinically used drug with high affinity for bone minerals) were covalently conjugated onto PGED brushes to produce dual-functional dental implants (Ti-AQ). The QPEI component imparted Ti-AQ with antibacterial abilities, and the ALN component could balance the cytotoxicity of a cationic antibacterial agent, improving the biocompatibility for osteoblast cells. The effective performances of anti-infection and osteointegration were demonstrated in a BAI animal model. The results indicated that Ti-AQ inhibited bacterial infection at the early stage and enhanced the osteointegration and biomechanical properties between the implants and bone tissues at the late stage. This study will provide one facile and universal strategy for the design and development of novel multifunctional antibacterial implants.
Keyphrases
- soft tissue
- silver nanoparticles
- early stage
- essential oil
- quantum dots
- anti inflammatory
- gene expression
- wound healing
- metal organic framework
- bone mineral density
- emergency department
- squamous cell carcinoma
- oxidative stress
- cell cycle arrest
- reduced graphene oxide
- electronic health record
- liquid chromatography
- smoking cessation
- molecularly imprinted
- simultaneous determination