DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes.

Hee Young JuJi Won LeeHee Won ChoJu Kyung HyunYoungeun MaEun Sang YiKeon Hee YooKi Woong SungRihwa ChoiHong Hoe KooSoo-Youn Lee

Published in: PloS one (2021)

Patients harboring NUDT15 variants demonstrated similar DNA-TGN concentrations even at low doses of 6MP and showed high variability in DNA-TGN. Particularly in patients with NUDT15 variants who need a reduced 6MP dose, DNA-TGN could be applied as a useful marker to monitor the therapeutic effect of 6MP.

Keyphrases

circulating tumor
cell free
single molecule
acute lymphoblastic leukemia
end stage renal disease
chronic kidney disease
copy number
nucleic acid
ejection fraction
newly diagnosed
prognostic factors
circulating tumor cells
acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation