Impact of Plasmodium falciparum gene deletions on malaria rapid diagnostic test performance.
Michelle L GattonAlisha ChaudhryJeff GlennScott WilsonYong AhAmy KongRosalynn L OrdRoxanne R Rees-ChannerPeter ChiodiniSandra IncardonaQin ChengMichael AidooJane CunninghamPublished in: Malaria journal (2020)
The pan-LDH-only RDTs evaluated performed well. Performance of Pf-LDH-detecting RDTs against wild-type P. falciparum does not necessarily predict performance against pfhrp2-deleted parasites. Furthermore, many, but not all HRP2-based RDTs, detect pfhrp2-negative/pfhrp3-positive samples, with implications for the HRP2-based RDT screening approach for detection and surveillance of HRP2-negative parasites.