Pituitary corticotroph tumour with adrenocortical cells: A distinct clinicopathologic entity with unique morphology and methylation profile.

Richard A HickmanJohn T GioncoPhyllis L FaustMichael L MillerJeffrey BruceGabrielle Page-WilsonMarc K RosenblumSylvia L Asa

Published in: Neuropathology and applied neurobiology (2021)

We describe a rare TPIT-positive corticotroph PitNET that is admixed with SF1-positive adrenocortical cells. This dimorphous population of cells showed no colocalisation between TPIT and SF1 by immunofluorescence, and an adrenocortical choristoma was favoured. Methylation array analysis revealed a novel methylation profile in relation to other pituitary neoplasms.

Keyphrases

induced apoptosis
cell cycle arrest
dna methylation
genome wide
oxidative stress
signaling pathway
gene expression
high throughput