New ent -kaurene-type nor-diterpene and other compounds isolated from Annona vepretorum Mart. (Annonaceae).
Camila de Souza AraújoDaniel Amando NeryAna Paula de OliveiraRaimundo Gonçalves de Oliveira-JúniorLarissa Araújo RolimNorberto Peporine LopesMaria Francilene de Souza SilvaCláudia do Ó PessoaRaimundo Braz-FilhoLívia Macedo DutraJosean Fechine TavaresLucas Silva AbreuMarcelo Sobral da SilvaJackson Roberto Guedes da Silva AlmeidaPublished in: Natural product research (2022)
A new nor- ent -kaurene diterpene and ten other compounds were isolated from Annona vepretorum stems, including four kaurene diterpenes, three alkamides, one sesquiterpene and two steroids. Their chemical structures were elucidated using spectroscopic methods, including 1D-, 2D-NMR, and HRESIMS. The absolute configuration of compounds 1 , 5 , 8 , 9 and 10 was confirmed by CD experiments. Compounds 1-5 and 8-10 were evaluated for cytotoxic activity using (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT method, against three human carcinoma cell lines: human colon (HCT-116), glioblastoma (SF295) and prostate (PC3). However, all isolated compounds exhibited low cytotoxic activity.