Prospective Assessment of Symptoms to Evaluate Asymptomatic SARS-CoV-2 Infections in a Cohort of Health Care Workers.
Emilie GoguetJohn H PowersCara H OlsenDavid R TribbleJulian DaviesLuca IllinikBelinda M Jackson-ThompsonMonique Hollis-PerrySantina E MaiolatesiSimon PollettChristopher A DuplessisGregory WangKathleen F RamseyAnatalio E ReyesYolanda AlcortaMimi A WongOrlando OrtegaEdward ParmeleeAlyssa R LindroseMatthew MoserEmily C SamuelsSi'Ana A CogginsElizabeth GraydonSara RobinsonWesley CampbellAllison M W MalloyLogan J VoegtlyCatherine E ArnoldRegina Z CerFrancisco MalagonKimberley A Lilly-BishopTimothy H BurgessChristopher C BroderEric D LaingEdward MitrePublished in: Open forum infectious diseases (2022)
These results suggest that asymptomatic SARS-CoV-2 infection in unvaccinated, immunocompetent adults is less common than previously reported. While infectious inoculum doses and patient factors may have played a role in the clinical manifestations of SARS-CoV-2 infections in this cohort, we suspect that the high rate of symptomatic disease was due primarily to participant attentiveness to symptoms and collection of symptoms in a standardized, prospective fashion. These results have implications for studies that estimate SARS-CoV-2 infection prevalence and for public health measures to control the spread of this virus.