Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus-Driven Cancers.

Soma Ghosh Tuhina Mazumdar Wei Xu Reid T Powell Clifford Stephan Li Shen Pooja Anil Shah Curtis R Pickering Jeffrey N Myers Jing Wang Mitchell J Frederick Faye M Johnson

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Our data support a model in which HPV-positive cancer cells maintain a balance of MAD2L1 and TRIP13 to allow mitotic exit and survival in the absence of Rb. Because it does not affect cells with intact Rb function, this novel combination may have a wide therapeutic window, enabling the effective treatment of Rb-deficient cancers.

Keyphrases

induced apoptosis
cell cycle arrest
electronic health record
high grade
big data
tyrosine kinase
oxidative stress
machine learning
childhood cancer
replacement therapy
pi k akt