Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment.

Jung-Min PyunYoung Ho ParkKeon-Joo LeeSangYun KimAndrew J SaykinKwangsik Nhonull null

Published in: Translational neurodegeneration (2021)

PRS could predict the conversion of MCI to dementia with a stronger association in APOE ε4 non-carriers than APOE ε4 carriers. This indicates PRS as a potential genetic predictor particularly for MCI with no APOE ε4 alleles.

Keyphrases

mild cognitive impairment
cognitive decline
high fat diet
gene expression
type diabetes
copy number