Epidermolysis bullosa simplex generalized severe induces a T helper 17 response and is improved by apremilast treatment.

E CastelaM K TulicA RozièresE BourratJ-F NicolasJ KanitakisP VabresDidier Bessis Mazereeuw-Hautier Juliette Fanny Morice-PicardD BatyF BerardJ-P LacourT PasseronChristine Chiaverini

Published in: The British journal of dermatology (2018)

Our study demonstrates the importance of inflammation in patients with EBS-gen sev and underlines the key role for T helper 17 cells in its pathogenesis. In addition, this study provides promising new therapeutic approaches for this disabling disorder.

Keyphrases

oxidative stress
regulatory t cells
induced apoptosis
early onset
drug induced
signaling pathway
replacement therapy