Targeting CD13/aminopeptidase N as a novel therapeutic approach for scleroderma fibrosis.
Sei MuraokaWilliam D BrodieMegan N MattichakMikel Gurrea-RubioYuzo IkariCaroline FosterM Asif AminNeha KhannaHafsa AminPhillip L CampbellSirapa VichaikulEllen N ModelMorgan M OmaraSteven PetrovskiKarly KozickiCamilia AmaristaAnna WebberMustafa AliPamela J PalisocJonatan HervosoJeffrey H RuthLam C TsoiJohn VargaJohann E GudjonssonZsuzsanna H McMahanDavid A FoxPei-Suen TsouPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
These results are the first to demonstrate a key role for sCD13 in SSc skin fibrosis, and suggest that targeting the sCD13-B1R signaling axis is a promising novel therapeutic approach for SSc.