Enzymatic cis- Decalin Formation in Natural Product Biosynthesis.
Masao OhashiDan TanJiayan LuCooper S JamiesonDaiki KanayamaJiahai ZhouKendall N HoukYi TangPublished in: Journal of the American Chemical Society (2023)
Stereoselective synthesis of cis- decalin structures using [4 + 2] cycloaddition is challenging. We explored the biosynthetic pathway of the fungal natural product fischerin ( 1 ) to identify a new pericyclase FinI that can catalyze such a reaction. The cocrystal structure of FinI, a predicted O- methyltransferase, with the product and SAM provides insight into cis- decalin formation in nature.