Contrasting activities of estrogen receptor beta isoforms in triple negative breast cancer.

Shunchao YanParama DeyYvonne ZieglerXin JiaoSung Hoon KimJohn A KatzenellenbogenBenita S Katzenellenbogen

Published in: Breast cancer research and treatment (2020)

ERβ2/ERβ5 and ERβ1 exhibit sharply contrasting activities in TNBC cells. Our findings imply that delineating the absolute amounts and relative ratios of the different ERβ isoforms might have prognostic and therapeutic relevance, and could enable better selection of optimal approaches for treatment of this often aggressive form of breast cancer.

Keyphrases

estrogen receptor
endoplasmic reticulum
induced apoptosis
breast cancer cells
cell cycle arrest
cell proliferation
endoplasmic reticulum stress
replacement therapy