Association between statin use, the vaginal microbiome, and Gardnerella vaginalis vaginolysin-mediated cytotoxicity.
Abdallah A AbdelmaksoudPhilippe H GirerdErin M GarciaJ Paul BrooksLauren M LeftwichNihar U ShethSteven P BradleyMyrna G SerranoJennifer M FettweisBernice HuangJerome F StraussGregory A BuckKimberly K JeffersonPublished in: PloS one (2017)
In this cross-sectional study, statin use was associated with reduced proportions of G. vaginalis and greater proportions of beneficial lactobacilli within the vaginal microbiome. The negative association between statin use and G. vaginalis may be related to inhibition of vaginolysin function.