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Selective inhibition of carboxypeptidase U may reduce microvascular thrombosis in rat experimental stroke.

Joachim C MertensWilliam BoisseauDorien LeenaertsLucas Di MeglioStéphane LoyauAnne-Marie LambeirCélina DucrouxMartine Jandrot PerrusJean-Baptiste MichelMichael MazighiDirk HendriksJean-Philippe Désilles
Published in: Journal of thrombosis and haemostasis : JTH (2020)
A pronounced activation of the CPU system was observed during tMCAO in rats. Selective inhibition of CPU with AZD9684 was able to reduce fibrin(ogen) deposition and brain edema, suggesting a reduction of MT but without a significant effect on final infarct volume.
Keyphrases
  • atrial fibrillation
  • pulmonary embolism
  • resting state
  • acute myocardial infarction
  • cerebral ischemia
  • oxidative stress
  • multiple sclerosis
  • functional connectivity
  • brain injury
  • subarachnoid hemorrhage