Selective inhibition of carboxypeptidase U may reduce microvascular thrombosis in rat experimental stroke.
Joachim C MertensWilliam BoisseauDorien LeenaertsLucas Di MeglioStéphane LoyauAnne-Marie LambeirCélina DucrouxMartine Jandrot PerrusJean-Baptiste MichelMichael MazighiDirk HendriksJean-Philippe DésillesPublished in: Journal of thrombosis and haemostasis : JTH (2020)
A pronounced activation of the CPU system was observed during tMCAO in rats. Selective inhibition of CPU with AZD9684 was able to reduce fibrin(ogen) deposition and brain edema, suggesting a reduction of MT but without a significant effect on final infarct volume.