Prophylactic or therapeutic administration of Holarrhena floribunda hydro ethanol extract suppresses complete Freund's adjuvant-induced arthritis in Sprague-Dawley rats.

Stephen AntwiDaniel Oduro-MensahJerry Asiedu-LarbiEbenezer Oduro-MensahOlga QuasieClara LewisDavid Darko-ObiriAugustine OclooLaud Kenneth Okine

Published in: Journal of inflammation (London, England) (2022)

HFE strongly suppressed Complete Freund's Adjuvant-induced arthritis and modulated regulators of inflammation, including IL-1α, - 6 and - 10. Taken together, the data suggest that HFE has potential for use as an agent for modulation of the inflammatory response.

Keyphrases

inflammatory response
oxidative stress
diabetic rats
high glucose
rheumatoid arthritis
early stage
drug induced
signaling pathway
transcription factor
electronic health record
endothelial cells
immune response
risk assessment
machine learning
deep learning
lps induced
artificial intelligence